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HILIC Stability

Our phase sustains higher stability towards basic, neutral, and acidic compounds. Relative retentions changes are minimized throughout the column life.

Hydrolytic stability of columns. Conditions:  Columns, (left) Silica (50 mm × 4.6 mm i.d.), (right) FructoShell (50 mm × 4.6 mm i.d.);

flow rate, 1.0 mL/min; eluent: Acetonitrile/ 25 mM NH4OAc pH 6.8, 75/25 (v/v); UV detection at 220 nm. BTMA = butyltrimethylamine

Armstrong et al. Anal. Methods, 2016, 8, 6038-6045

Selectivity


Our column show competitive hydrophilic character while maintaining a low silanol activity

Plot of electrostatic character vs. hydrophilicity character for the evaluated HILIC phases. Conditions: eluent, ACN/25 mM ammonium acetate, pH 6.8, 80/20 (v/v);

flow rate, 1.0 mL/min; UV detection at 254 nm.

Reproducibility


FructoShell-N (150 mm x 4.6 mm i.d.) Column Stability Test.Conditions:eluent, ACN/25 mM NH4OAc, 72/25 (v/v); flow rate, 2.0 mL/min
Order of elution: Uracil, Adenosine, Adenine, Cytosine

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